Nine out of every ten medical students, residents, and fellows attempt to write a manuscript during their training. Yet, after finishing the training only 1 or 2 would continue to write scientific manuscripts due to the effort involved in preparing a manuscript. Most medical students, residents, fellows, and even junior faculty consider writing a scientific manuscript harder than working grueling hours on the clinical service. The manual of scientific manuscript writing was developed to guide for medical students, residents, fellows, and junior faculty by providing a step by step pathway for successful preparation of a manuscript. The manual is expected to reduce the usual 3 and 6 months (at times frustrating) effort to a 1 to 2 week streamlined process to complete a manuscript.